An RNA platform to help keep the world healthy
mRNA’s characteristics make it a highly valuable molecule for human health. Thanks to mRNA, effective Covid-19 vaccines were quickly developed to tame the Covid pandemic.
byoRNA is working on a disruptive bioproduction technology that will help exploit the therapeutic potential of messenger RNA.
Produce abundant and cheap RNA to save kids and elders all over the world.
The current mRNA production process is based on a very expensive "cell-free" system that presents limitations with regards to quantities and characteristics of future treatments for rare diseases and cancers.
Current production methods will limit access of young to elderly patients to these innovative treatments.
Eucaryotic cells possess a great machinery to produce natural mRNA.
However, this RNA is rapidly degraded inside the cell cytoplasm thus preventing the production of massive quantities of mRNA.
Traditional, mature fermentation techniques must hence be improved.
We will develop innovative technologies to isolate the mRNA of interest inside a cell compartment where it will be able to accumulate without being degraded.
Our proof-of-concept shows that this innovative approach is already 100 times more efficient than normal yeast mRNA accumulation and produces target mRNA that is highly effective..
We, as Founders of byoRNA, dream that one day, we will have a wall covered with photos of kids and teenagers, many of them, playing with friends, laughing, crying, celebrating anniversaries with their families and friends.
Kids that we will have helped to save.
Our bet: "bio" RNA from eucaryotic cells
We believe that mRNA produced from our developed cell platforms will be cheaper and easier to manufacture than IVT (in vitro) mRNA, making it accessible to everyone, including patients from poorer countries.
This belief is grounded in the fact that contrary to IVT production which demands many expensive enzymes and components (many of them produced through additional in vivo cell cultures), manufacturing mRNA in our specific cell systems is a single process that mimics Nature and requires mostly... sugar!
On top of that, eukaryotic-based RNA, like (eukaryotic) mammalian production of mRNA, is likely to produce an RNA of better quality.
1- Generation of cell lines
Thanks to synthetic biology and experimental design, the cell lines are optimized for a better expression of the mRNA of interest.